What lies beneath the skin.
نویسندگان
چکیده
To cite: Sahai M, Oliver AM. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2013008584 DESCRIPTION A 46-year-old man with a history of hypertension presented with a 6-month history of progressive, diffuse skin thickening. He denied any exposure to new drugs, toxins or contrast material, had no history of Raynaud’s disease or endocrine disorder. Physical examination revealed diffuse skin tightness, limited range of motion of joints and sparse hair with leonine facies (figures 1 and 2). A skin biopsy revealed fibroblast proliferation (figure 3) and special staining with Alcian Blue (figure 4) revealed an increased mucin between and among collagen bundles resulting in the diagnosis of scleromyxedema. Further work-up revealed a bone marrow biopsy consistent with a plasma cell dyscrasia. Patient was subsequently treated with dexamethasone, bortezomib and thalidomide resulting in stabilisation of skin fibrosis and resolution of plasma cell dyscrasia. Scleromyxedema is a rare connective tissue disorder that has been associated with paraproteinemias. It is characterised by cutaneous eruption of small, waxy, firm papules commonly occurring over
منابع مشابه
Movement disorders: what lies beneath?
Journal of Neurology Neurosurgery & Psychiatry (ISSN No: 0022-3050) is published monthly by BMJ Publishing Group and is distributed in the USA by Air Business Ltd. Periodicals postage paid at Jamaica NY 11431 POSTMASTER: send address changes to Journal of Neurology Neurosurgery & Psychiatry, Air Business Ltd, c/o Worldnet Shipping Inc., 156-15, 146th Avenue, 2nd Floor, Jamaica, NY 11434, USA. E...
متن کاملWhat Lies Beneath the Science Achievement Gap: The Challenges of Aligning Science Instruction With Standards and Tests
متن کامل
Thickness of Crust in the West of Iran Obtained from Modeling of Ps Converted Waves
Receiver functions are usually used to detect Ps converted waves and are especially useful to picture seismic discontinuities in the crust and upper mantle. In this study, the P receiver function technique beneath the west Iran is used to map out the lateral variation of the Moho boundary. The teleseismic data (Mb ≥5.5, epicentral distance between 30˚-95˚) recorded from 2004 to 2016 at 17 perma...
متن کاملWhat lies beneath: in vivo stem cell imaging.
No other branch of science is quite so laden with expectation. But while corralling stem cells for viable therapies, researchers have found themselves asking an entirely separate question: How do we track them?
متن کاملEvaluating ischemic stroke subtypes: does the retinal microvasculature hold clues to what lies beneath?
Stroke welcomes Letters to the Editor and will publish them, if suitable, as space permits. They should not exceed 750 words (including references) and may be subject to editing or abridgment. Please submit letters in duplicate, typed double-spaced. Include a fax number for the corresponding author and a completed copyright transfer agreement form (available online at http://stroke.ahajournals....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- BMJ case reports
دوره 2013 شماره
صفحات -
تاریخ انتشار 2013